LC-MS/MS BIOANALYSIS OF SMALL AND LARGE MOLECULES

Our Platform Suite

LC – MS/MS Bioanalysis

Immunoassay Bioanalysis

Biomarkers

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Expert LC-MS/MS bioanalysts and world-class equipment

Mass spectrometry technology is a powerful analytical tool that plays a key role in drug development. Delivering accurate, robust and timely data is critical to every successful pre-clinical and clinical trial.

Agilex Biolabs conducts high performance, regulated bioanalysis by liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis of small molecules, peptides and proteins.

Our dedicated LC-MS/MS team of experts averages over 15 years of experience each. Our areas of expertise include: new chemical entities (NCEs), sugars, nucleotides, enantiomers, steroids, prodrugs, peptides, immunosuppressants, nanoparticles, neurotransmitters, oligonucleotides and polymeric mixtures.

With six Sciex API 4000™ LC-MS/MS systems offering high throughput, high sensitivity and high-performance quantitation, the extended mass range of this instrumentation to 3000 m/z allows quantitative analysis of peptides and multiply charged small proteins. Our Sciex API QTRAP 5500 LC-MS/MS system offers even further sensitivity.

Assay development

Our LC-MS/MS team are experts at developing robust, compliant Assays to quantify novel compounds, including:

  • Pharmacokinetic (PK) assays
  • Pharmacodynamic (PD) assays
  • Biomarker assays
  • Cannabis assays

Assay validation

​Our LC-MS/MS team are experts at full and partial validation and method transfer to ensure data integrity, validity and reliability.

Sample analysis

Our laboratory platforms perform high throughput and high performance sample analysis, including:

  • Pharmacokinetic (PK) analysis
  • Pharmacodynamics (PD) biomarker analysis
  • Peptide/protein assays via hybrid immunocapture mass spectrometry
  • Toxicokinetic (TK) bioanalysis

Validated assays

Compound (-metabolite)Species & MatrixLLOQ LevelLLOQ Units
Acetyl-L-carnitineHuman urine1nmol/L
- L-carnitine2.5nmol/L
Cannabidiol (CBD)Human plasma100pg/mL
Cannabinol (CBN)Human plasma100pg/mL
CarboplatinHuman plasma50ng/mL
CapsaicinHuman plasma0.01ng/mL
CarnitineHuman muscle5nmol/L
Human plasma2.5nmol/L
ClioquinolHuman plasma500ng/mL
DextromethorphanHuman plasma0.2ng/mL
- Dextrorphan (Total)2.5ng/mL
- 3-Methoxymorphinan0.1ng/mL
DiclofenacHuman skin50ng/ disc
DiclofenacHuman plasma0.2ng/mL
- 4'Hydroxydiclofenac0.2ng/mL
DihydroartemisininHuman plasma10ng/mL
DuloxetineHuman plasma0.1ng/mL
EfavirenzHuman plasma20ng/mL
EntecavirHuman plasma20pg/mL
EmtricitabineHuman plasma20ng/mL
EtoposideHuman plasma100ng/mL
EverolimusHuman whole blood0.5ng/mL
FentanylHuman plasma0.01ng/mL
R-FlurbiprofenHuman plasma100ng/mL
Glucagon peptideHuman plasma0.04ng/mL
IbuprofenHuman plasma2000ng/mL
R-IbuprofenHuman plasma200ng/mL
S-IbuprofenHuman plasma200ng/mL
IcotinibHuman plasma10pg/mL
ItraconazoleHuman plasma2ng/mL
- Hydroxy-itraconazole4ng/mL
R-KetamineHuman plasma1ng/mL
S-KetamineHuman plasma1ng/mL
KetamineHuman plasma2ng/mL
- Nor-Ketamine2ng/mL
Lidocaine Human skin100ng/ disc
Lidocaine Human plasma0.2ng/mL
MannitolHuman serum100ng/mL
MidazolamHuman plasma100pg/mL
- Alpha-hydroxymidazolam100pg/mL
MilrinoneHuman plasma1ng/mL
NestoroneHuman plasma10pg/mL
NicotineHuman plasma1ng/mL
Octyl salicylateHuman plasma7.5ng/mL
OxycodoneHuman plasma0.2ng/mL
-Noroxycodone0.2ng/mL
OxycodoneHuman plasma100pg/mL
-Noroxycodone100pg/mL
-Oxymorphone10pg/mL
OxymorphoneHuman plasma25pg/mL
- 6-beta Hydroxy Oxymorphone25pg/mL
ParoxetineHuman plasma500ng/mL
Phenylepherine (Total)Human plasma20ng/mL
PiperaquineHuman plasma5ng/mL
Propionyl L-carnitineHuman plasma0.1nmol/mL
Propionyl L-carnitinerat, human liver microsomes0.5nmol/mL
- L-carnitine 2.5nmol/mL
PseudoephedrineHuman plasma10ng/mL
QuinidineHuman plasma2ng/mL
SildenafilHuman plasma0.5ng/mL
- Desmethyl Sildenafil0.5ng/mL
TenofovirHuman plasma5ng/mL
TreprostinilHuman plasma10pg/mL
Tetrahydrocannabinol (THC)Human plasma100pg/mL
- Hydroxy-tetrahydrocannabinol (THC)100pg/mL
- Nor-carboxy-tetrahydrocannabinol (THC)1ng/mL
Vessel Dilator (peptide)Human plasma0.2ng/mL

LC-MS/MS Bioanalysis

Immunoassay Bioanalysis

Biomarkers

Speak to a Scientist

We look forward to discussing your project. Contact Us